Evidence map›Paper›PMID 41727120›Full record

ArticlebioRxiv : the preprint server for biology2026

Electrical stimulation combined with p27Kip1 inactivation drives proliferative neurogenic reprogramming of Mueller glia in the adult mouse retina.

Megan L Stone, Joel Jovanovic, Edward M Levine

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Megan L StoneDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, 37232.
Joel JovanovicVanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, 37232.
Edward M LevineDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, 37232.ORCID 0000-0003-1725-2805

Funding

Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Vsx2 Dependent Regulation of Retinal Progenitor Cell PropertiesR01EY013760 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LEVINE, EDWARD M · 2003 to 2024
$6.9M
Training in Vision ResearchT32EY007135 · NEI · VANDERBILT UNIVERSITY · PI GEOFFREY F WOODMAN · 1994 to 2026
$5.8M
Neurogenic potential of murine Müller glia following retinal injury and conditional inactivation of p27Kip1R21EY033473 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LEVINE, EDWARD M · 2022 to 2023
$476k
Confocal Microscope for Live Embryo Imaging in a Shared Resource FacilityS10RR027396 · NCRR · VANDERBILT UNIVERSITY · PI PRINCE, LAWRENCE S · 2010 to 2010
$460k
Reprogramming adult murine Müller glia via L-Myc expressionF31EY035554 · NEI · VANDERBILT UNIVERSITY · PI STONE, MEGAN · 2023 to 2025
$102k
NCRR NIH HHS S10 RR027396NEI NIH HHS F31 EY035554NEI NIH HHS P30 EY008126NEI NIH HHS R01 EY013760NEI NIH HHS R21 EY033473NEI NIH HHS T32 EY007135
6 · The paper itself

Abstract

Mueller glial reprogramming studies demonstrate that mammalian Mueller glia can be induced to proliferate and/or engage in neural differentiation, as occurs naturally in teleost fish. A major objective is the identification of combined strategies that promote both robust proliferation and neurogenesis. These studies would benefit from a translatable screening platform that enables controlled perturbation, maintained tissue context and longitudinal analysis, such as 3D culture for first tier analysis of reprogramming strategies. Here, we validate a 3D retinal culture for Mueller glial reprogramming studies by recapitulating key signatures of an

Indexed as

adult mammalian retinabioelectric signalingcell-state transitioncell type-specific proliferation reportercombinatorial frameworkelectrical stimulationex vivofate competenceGlial plasticityiCOUNTintrinsic-extrinsic cue integrationMueller glianeurogenesisNeurogenic reprogrammingp27Kip1 inactivationprogenitor-state acquisitionproliferationproliferation-neurogenesis gapproliferative reprogrammingproneural marker expressionreprogrammingretinal regenerationretinal repairsynergistic coupling

Identifiers

PMID41727120
PMCPMC12918897

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.