Evidence map›Paper›PMID 41727096›Full record

ArticlebioRxiv : the preprint server for biology2026

TARGETING INSULO-FRONTAL PATHWAY TO REDUCE STRESS-EVOKED COGNITIVE RIGIDITY.

Shaorong Ma, Kuan Hong Wang, Yi Zuo

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Shaorong MaDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0003-4643-8393
Kuan Hong WangDepartment of Neuroscience, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-2249-5417
Yi ZuoDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.

Funding

Fronto-insular network in cognitive-affective interactions during decision-makingR01MH127737 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Kuan Hong Wang, Yi Zuo · 2022 to 2026
$2.8M
U24 NEW Brain Aging Diversity SupplementU24AG072701 · NIA · UNIVERSITY OF ROCHESTER · PI CONWELL, YEATES, LIN, FENG VANKEE · 2021 to 2024
$2.6M
Identifying signatures of brain aging through heterochronic blood exchangeR01AG071787 · NIA · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MESSERSMITH, PHILLIP B, MOURRAIN, PHILIPPE · 2021 to 2025
$2.3M
Synaptic circuit mechanisms underlying psilocybin's therapeutic effects in the stressed brainR01MH136381 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2024 to 2024
$679k
NIA NIH HHS R01 AG071787NIA NIH HHS U24 AG072701NIMH NIH HHS R01 MH127737NIMH NIH HHS R01 MH136381
6 · The paper itself

Abstract

The anterior insular cortex (aIC), a central hub of the salience network, is engaged by cognitive flexibility tasks

Identifiers

PMID41727096
PMCPMC12918876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.