Evidence map›Paper›PMID 41727091›Full record

ArticlebioRxiv : the preprint server for biology2026

Universal Baseline for

Kejia Yan, Guilherme M Lima, Tara Bahadur, Vincent Albert, Zoe O'Gara, Gary Bao, Christin Kossmann, William Kirby, Fernando B Mejia, Matthew L Michnik and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kejia YanDepartment of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.ORCID 0009-0000-3181-3563
Guilherme M LimaDepartment of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.ORCID 0000-0002-3268-6081
Tara Bahadur48Hour Discovery Inc., Edmonton, AB, T6G 2M9, Canada.
Vincent Albert48Hour Discovery Inc., Edmonton, AB, T6G 2M9, Canada.
Zoe O'Gara48Hour Discovery Inc., Edmonton, AB, T6G 2M9, Canada.
Gary Bao48Hour Discovery Inc., Edmonton, AB, T6G 2M9, Canada.
Christin KossmannZealand Pharma A/S, Søborg, Denmark.
William Kirby48Hour Discovery Inc., Edmonton, AB, T6G 2M9, Canada.
Fernando B MejiaGraduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, Washington 98195, United States.
Matthew L Michnik48Hour Discovery Inc., Edmonton, AB, T6G 2M9, Canada.
Kristen Maiorana48Hour Discovery Inc., Edmonton, AB, T6G 2M9, Canada.
Ratmir DerdaDepartment of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.ORCID 0000-0003-1365-6570

Funding

Chemical Genetic Analysis of RAS SignalingR01GM145011 · NIGMS · UNIVERSITY OF WASHINGTON · PI MALY, DUSTIN J · 2022 to 2025
$1.5M
Developing a Chemically-Controlled RAS ToolsetF31GM155953 · NIGMS · UNIVERSITY OF WASHINGTON · PI BANALES MEJIA, FERNANDO · 2024 to 2025
$90k
NIGMS NIH HHS F31 GM155953NIGMS NIH HHS R01 GM145011
6 · The paper itself

Abstract

Genetically encoded (GE) libraries enable identification of high-affinity ligands for diverse molecular targets through iterative

Indexed as

baselineBiochemistryBiological Sciencesdiversityphage displayreproducibility

Identifiers

PMID41727091
PMCPMC12918800

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.