Evidence map›Paper›PMID 41727090›Full record

ArticlebioRxiv : the preprint server for biology2026

Menaquinone depletion resensitises bedaquiline-resistant tuberculosis.

Jennefer Wetzel, John Dallow, Ellie Davis, William H Pearson, Stijn Daems, Matthias Govaerts, Joyce Hereijgers, Joke Sprangers, Barry Truebody, Valerie Maes and 35 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Jennefer WetzelJohnson & Johnson, Beerse, Belgium.
John DallowDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Ellie DavisDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
William H PearsonDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Stijn DaemsJohnson & Johnson, Beerse, Belgium.
Matthias GovaertsJohnson & Johnson, Beerse, Belgium.
Joyce HereijgersCharles River Laboratories, Turnhoutseweg 30, 2340, Beerse, Belgium.
Joke SprangersCharles River Laboratories, Turnhoutseweg 30, 2340, Beerse, Belgium.
Barry TruebodyAfrica Health Research Institute, University of KwaZulu Natal, Durban, South Africa.
Valerie MaesJohnson & Johnson, Beerse, Belgium.
Vera van HasseltCharles River Laboratories, Turnhoutseweg 30, 2340, Beerse, Belgium.
Annelies LeemansJohnson & Johnson, Beerse, Belgium.
Venugopal PujariMicrobiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, CO, 80523, USA.
Ann VosJohnson & Johnson, Beerse, Belgium.
Carlos M Martínez ViturroGlobal Discovery Chemistry, Janssen-Cilag SA, a Johnson & Johnson company, C. Río Jarama, 75A, 45007 Toledo, Spain.
José Enrique GómezGlobal Discovery Chemistry, Janssen-Cilag SA, a Johnson & Johnson company, C. Río Jarama, 75A, 45007 Toledo, Spain.
Mirte PeetersCharles River Laboratories, Turnhoutseweg 30, 2340, Beerse, Belgium.
Michelle GerberVaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada.
Nandini ChhabraVaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada.
Annelies WoutersJohnson & Johnson, Beerse, Belgium.
Melissa EveraertsJohnson & Johnson, Beerse, Belgium.
Hannah PainterDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Raisha FathimaDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Sam J WillcocksDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Cadi DaviesDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Valerie RaeymaekersJohnson & Johnson, Beerse, Belgium.
Taane G ClarkDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Ruxandra Draghia-AkliJohnson & Johnson, Spring House, Pennsylvania, USA.
Helen FletcherDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Marnix Van LoockJohnson & Johnson, Beerse, Belgium.
Martin L HibberdDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Serge MostowyDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Dean C CrickMicrobiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, CO, 80523, USA.
Alexander S PymJohnson & Johnson, High Wycombe, UK.
Kirandeep SambyJohnson & Johnson Pvt. Ltd, Gurugram 122003, India.
Paul JacksonJohnson & Johnson, La Jolla, California, USA.
Andrés A TrabancoGlobal Discovery Chemistry, Janssen-Cilag SA, a Johnson & Johnson company, C. Río Jarama, 75A, 45007 Toledo, Spain.
Gerald Larrouy-MaumusCentre for Bacterial Resistance Biology, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, UK.
Adrie J C SteynAfrica Health Research Institute, University of KwaZulu Natal, Durban, South Africa.
Bart StoopsJohnson & Johnson, Beerse, Belgium.
Neeraj DharVaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada.
Clara Aguilar-PérezJohnson & Johnson, Beerse, Belgium.
Dirk A LamprechtJohnson & Johnson, Beerse, Belgium.
Richard J WallDepartment of Infection Biology, Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Anil KoulJohnson & Johnson, Beerse, Belgium.

Funding

Interplay between the Mtb electron transport chain and carbon metabolismR01AI137043 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2019 to 2023
$2.1M
Target and Non-target Based Resistance to Bedaquiline in South AfricaR01AI152110 · NIAID · SEFAKO MAKGATHO HEALTH SCIENCES UNIVERSITY · PI MAKHADO, NDIVHU, STEYN, ADRIE JC · 2020 to 2024
$1.7M
NIAID NIH HHS R01 AI137043NIAID NIH HHS R01 AI152110Wellcome Trust
6 · The paper itself

Abstract

Tuberculosis remains a leading cause of global mortality, and rising bedaquiline resistance threatens the effectiveness of current drug-resistant treatment regimens. Bedaquiline resistance typically arises through mutations in

Identifiers

PMID41727090
PMCPMC12919086

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.