Evidence map›Paper›PMID 41727072›Full record

ArticlebioRxiv : the preprint server for biology2026

Histone H3 availability is more important for development than H3.2 versus H3.3 subtype identity.

Jeanne-Marie E McPherson, Claire Sykes, Lucy C Grossmann, Christina H Hill, Mary P Leatham-Jensen, Robert J Duronio, Daniel J McKay

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jeanne-Marie E McPhersonCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.ORCID 0000-0002-3379-5626
Claire SykesDepartment of Biology, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID 0009-0007-8546-8241
Lucy C GrossmannDepartment of Biology, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID 0009-0006-7890-6699
Christina H HillDepartment of Biology, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID 0009-0004-5147-502X
Mary P Leatham-JensenDepartment of Biology, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-6416-021X
Robert J DuronioCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.ORCID 0000-0001-6469-6965
Daniel J McKayCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, 27599 USA.ORCID 0000-0001-8226-0604

Funding

NRSA in GeneticsT32GM135128 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay, JEFF J. SEKELSKY · 2020 to 2026
$5.1M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
Epigenetic Control of the Cell Cycle During Animal DevelopmentR35GM145258 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert J Duronio · 2022 to 2026
$2.3M
Interrogating the roles of canonical versus variant histone H3 in genome function during agingF31AG079632 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCPHERSON, JEANNE-MARIE · 2023 to 2024
$79k
NIA NIH HHS F31 AG079632NIGMS NIH HHS R35 GM128851NIGMS NIH HHS R35 GM145258NIGMS NIH HHS T32 GM135128
6 · The paper itself

Abstract

The distinct contributions of replication-dependent and replication-independent histones to development and genome function remain unclear. In this study, we investigate how the distinct protein identities of the histone H3.2 and H3.3 subtypes contribute to development and gene regulation in

Indexed as

ChromatinH3H3.3HIRAhistone chaperonesreplication-dependent histonesreplication-independent histonesvariant histones

Identifiers

PMID41727072
PMCPMC12918891

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.