Evidence map›Paper›PMID 41727061›Full record

ArticlebioRxiv : the preprint server for biology2026

Conserved Molecular Responses to Arsenite Exposure in

Shannon R Smoot, Jay Tourigny, Jessica M Holsopple-Bowen, Alexander J Fitt, Yadira Pena-Garcia, Matt R Lowe, Darcy A Rose, Noelle C Zolman, Grace H Thrasher, Satyavsh S Arya and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shannon R SmootDepartment of Biology, Indiana University, Bloomington, IN 47405.
Jay TourignyDepartment of Biology, Indiana University, Bloomington, IN 47405.
Jessica M Holsopple-BowenDepartment of Biology, Indiana University, Bloomington, IN 47405.
Alexander J FittDepartment of Biology, Indiana University, Bloomington, IN 47405.
Yadira Pena-GarciaDepartment of Biology, Indiana University, Bloomington, IN 47405.ORCID 0009-0002-0429-4010
Matt R LoweDepartment of Biology, Indiana University, Bloomington, IN 47405.
Darcy A RoseDepartment of Biology, Indiana University, Bloomington, IN 47405.
Noelle C ZolmanDepartment of Biology, Indiana University, Bloomington, IN 47405.
Grace H ThrasherDepartment of Biology, Indiana University, Bloomington, IN 47405.
Satyavsh S AryaDepartment of Biology, Indiana University, Bloomington, IN 47405.
Hunter B ViresDepartment of Biology, Indiana University, Bloomington, IN 47405.
Emma C AdamsDepartment of Biology, Indiana University, Bloomington, IN 47405.
John K ColbourneCentre for Environmental Research and Justice, and School of Biosciences, University of Birmingham, Birmingham, United Kingdom, B15 2TT.ORCID 0000-0002-6966-2972
Joseph R ShawO'Neill School of Public and Environmental Affairs, Indiana University, Bloomington, IN, USA.
Brian OliverO'Neill School of Public and Environmental Affairs, Indiana University, Bloomington, IN, USA.
Travis NemkovDepartment of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO, 80045, USA.ORCID 0000-0001-8566-7119
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO, 80045, USA.ORCID 0000-0002-2258-6490
Thomas C KaufmanDepartment of Biology, Indiana University, Bloomington, IN 47405.
Jason M TennessenDepartment of Biology, Indiana University, Bloomington, IN 47405.ORCID 0000-0002-3527-5683

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
NCATS NIH HHS UL1 TR002529
6 · The paper itself

Abstract

Arsenic exposure is a pervasive global health threat strongly associated with increased risk of morbidities such as diabetes, cardiovascular disease, and cancer. Despite extensive studies describing the dangers of arsenic exposure, the molecular initiating events that link arsenic to chronic disease onset and progression remain poorly defined. To address this knowledge gap, we combined time-resolved transcriptomic and metabolomic profiling of adult

Identifiers

PMID41727061
PMCPMC12919075

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.