Evidence map›Paper›PMID 41727057›Full record

ArticlebioRxiv : the preprint server for biology2026

Global Proteomic Analysis of Colorectal Cancers Stratified by Microsatellite Instability Subtype Reveals Protein Differences.

Fernando Tobias, Emily R Sekera, Xingzhao Xiong, Fei Fang, Heather Hampel, Rachel Pearlman, Xiaowen Liu, Liangliang Sun, Amanda B Hummon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fernando TobiasDepartment of Chemistry and Biochemistry and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, 43210, USA.ORCID 0000-0002-4085-4188
Emily R SekeraDepartment of Chemistry and Biochemistry and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, 43210, USA.ORCID 0000-0002-1668-3227
Xingzhao XiongDeming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-9384-4573
Fei FangDepartment of Chemistry, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0003-0829-9871
Heather HampelCity of Hope, Duarte Cancer Center, Duarte, CA 91010, USA.ORCID 0000-0001-7558-9794
Rachel PearlmanDepartment of Internal Medicine and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, 43210, USA.ORCID 0000-0002-9293-5860
Xiaowen LiuDeming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0003-4139-1127
Liangliang SunDepartment of Chemistry, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-8939-5042
Amanda B HummonDepartment of Chemistry and Biochemistry and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, 43210, USA.ORCID 0000-0002-1969-9013

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Spatial SILAC: Examining the Proteome in 3D Cell CulturesR01GM110406 · NIGMS · UNIVERSITY OF NOTRE DAME · PI HUMMON, AMANDA B. · 2014 to 2022
$3.0M
Quantitative top-down proteomics of human colorectal cancer cells and tumorsR01CA247863 · NCI · MICHIGAN STATE UNIVERSITY · PI HUMMON, AMANDA B., LIU, XIAOWEN · 2021 to 2025
$1.9M
Advancing top-down proteomics with capillary electrophoresis-mass spectrometryR35GM153479 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Liangliang Sun · 2024 to 2026
$1.4M
Chemical Specific Measurements of Cellular Heterogeneity in OrganoidsR35GM158423 · NIGMS · OHIO STATE UNIVERSITY · PI Amanda B. Hummon · 2025 to 2026
$833k
Electroblotting through enzymatic membranes to enhance MALDI tissue imaging of proteinsR21AG062144 · NIA · OHIO STATE UNIVERSITY · PI HUMMON, AMANDA B. · 2019 to 2020
$424k
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA247863NIA NIH HHS R21 AG062144NIGMS NIH HHS R01 GM110406NIGMS NIH HHS R35 GM153479NIGMS NIH HHS R35 GM158423
6 · The paper itself

Abstract

Lynch syndrome, historically known as hereditary nonpolyposis colorectal cancer, is caused by germline mutations in the DNA mismatch repair (MMR) genes,

Indexed as

Double Somatic MMR MutationInflammatory MarkersLynch SyndromeMLH1 hypermethylationMSH-HProteomics

Identifiers

PMID41727057
PMCPMC12922705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.