Evidence map›Paper›PMID 41727040›Full record

ArticlebioRxiv : the preprint server for biology2026

Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function.

Nicole E Scharping, Xuezhen Ge, Maria Inês Matias, Fulin Jiang, Allison Cafferata, Maximilian Heeg, Alexander Monell, Giovanni Galletti, Kitty P Cheung, Angelica Rock and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Nicole E ScharpingSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Xuezhen GeSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Maria Inês MatiasLa Jolla Institute for Immunology, La Jolla, CA, USA.
Fulin JiangSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Allison CafferataSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Maximilian HeegSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Alexander MonellSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Giovanni GallettiSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-6613-2354
Kitty P CheungSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Angelica RockSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Nick ThaoSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Sydnye L ShuttleworthDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Michael A BauerDepartment of Biomedical Informatics, University of Arkansas for Medical Science, Little Rock, AR, USA.
Kennidy K TakeharaSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Amir FerrySchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Sara QuonSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Brian KossDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Samuel A MyersLa Jolla Institute for Immunology, La Jolla, CA, USA.
Eric J BennettSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Ananda W GoldrathSchool of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.

Funding

Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
Regulation of T cell immunity to viral infectionR01AI072117 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2008 to 2022
$5.4M
Systems-level identification of key regulators deciding immune cell stateR01AI150282 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, WEI · 2020 to 2024
$3.5M
T cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0M
Leveraging ubiquitin-dependent regulatory mechanisms to improve proteome quality in health and diseaseR35GM148339 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric J Bennett · 2023 to 2026
$2.1M
Discovering T cell proteome turnover dynamics to overcome the solid tumor microenvironmentDP5OD031863 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI KOSS, BRIAN · 2021 to 2025
$1.9M
Tissue-specific adaptions to promote localized T cell memoryR01AI179952 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2024 to 2026
$1.8M
Ubiquitin ligase regulation of tissue-resident T cell and anti-tumor activityR21AI178362 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2023 to 2024
$435k
Tumor-infiltrating T cell metabolic dysfunction and genetic reprogramming for effective immunotherapyK00CA222711 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHARPING, NICOLE E · 2020 to 2023
$360k
Understanding Prostate Resident Memory T CellsF31AI176705 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAKEHARA, KENNIDY · 2024 to 2025
$64k
NCI NIH HHS K00 CA222711NIAID NIH HHS F31 AI176705NIAID NIH HHS R01 AI072117NIAID NIH HHS R01 AI150282NIAID NIH HHS R01 AI179952NIAID NIH HHS R21 AI178362NIAID NIH HHS R37 AI067545NIGMS NIH HHS R35 GM148339NIGMS NIH HHS T32 GM133351NIH HHS DP5 OD031863
6 · The paper itself

Abstract

Tumor-infiltrating lymphocytes (TIL) often fail to restrain tumor growth due to progressive differentiation to an 'exhausted' state. In healthy tissues, tissue-resident memory T cells (T

Identifiers

PMID41727040
PMCPMC12919242

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.