Evidence map›Paper›PMID 41727017›Full record

ArticlebioRxiv : the preprint server for biology2026

EBV reprograms autoreactive anti-CNS B cells as antigen presenting cells in multiple sclerosis.

Shady Younis, Sajede Rasouli, Jacob W Loeffler, Neda Sattarnezhad, Ya'el Courtney, Salvinaz I Moutusy, Shaghayegh Jahanbani, Mahesh Pandit, Anna Tomczak, Heidi H Wong and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shady YounisDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0002-4319-1738
Sajede RasouliDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0002-9235-0336
Jacob W LoefflerDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0003-2234-4309
Neda SattarnezhadDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0002-7022-4144
Ya'el CourtneyDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0002-4562-500X
Salvinaz I MoutusyDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0009-0001-7206-2185
Shaghayegh JahanbaniDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0001-7789-4856
Mahesh PanditDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0009-0007-9111-444X
Anna TomczakDivision of Neuroimmunology, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 213 Quarry Road, Palo Alto, CA 94304, United States.ORCID 0009-0000-2973-8592
Heidi H WongDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0009-0002-0402-300X
Orr SharpeDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0003-1986-7555
Paul J UtzDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0003-1181-1565
Eric MeffreDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0003-4326-0171
Lucas B KippDivision of Neuroimmunology, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 213 Quarry Road, Palo Alto, CA 94304, United States.ORCID 0000-0002-5178-5464
Jeffrey E DunnDivision of Neuroimmunology, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 213 Quarry Road, Palo Alto, CA 94304, United States.ORCID 0000-0002-1721-6081
Tobias V LanzDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0001-7106-8801
Lawrence SteinmanDivision of Neuroimmunology, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 213 Quarry Road, Palo Alto, CA 94304, United States.ORCID 0000-0002-2437-2250
William H RobinsonDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305, United States.ORCID 0000-0003-4385-704X

Funding

Investigating Mucosal Breaks in the Initiation and Progression of Rheumatoid ArthritisR01AR078268 · NIAMS · STANFORD UNIVERSITY · PI ORANGE, DANA ELIZABETH, ROBINSON, WILLIAM H · 2021 to 2025
$3.1M
Deciphering the Role of Epstein-Barr Virus Molecular Mimicry and B cell Transformation in Multiple SclerosisR01AI173189 · NIAID · STANFORD UNIVERSITY · PI Tobias Volker Lanz, William H Robinson · 2023 to 2026
$2.3M
Defining the Role of Epstein-Barr Virus in Multiple SclerosisK23AI177932 · NIAID · STANFORD UNIVERSITY · PI Neda Sattarnezhad Oskouei · 2024 to 2026
$579k
NIAID NIH HHS K23 AI177932NIAID NIH HHS R01 AI173189NIAMS NIH HHS R01 AR078268
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease targeting the central nervous system (CNS). MS develops almost exclusively in individuals previously infected with Epstein-Barr virus (EBV)

Identifiers

PMID41727017
PMCPMC12919047

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.