ArticlebioRxiv : the preprint server for biology2026
Metabolic Rewiring at the Pyruvate Node Drives Severe Pneumonia and T-Cell Suppression in Serotype 3
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Serotype 3 (ST3) Methods: We investigated oxygen-dependent fitness, virulence, and lung pathology in the ST3 strain WU2 and isogenic Δ Results: ST3-strain exhibited a unique oxygen-sensitive growth defect at 21% O Conclusions: The SpxB-dependent pathway orchestrates ST3 virulence by enabling metabolic adaptation and driving bleb-mediated epithelial invasion and immune evasion in the lung. These bacterium-laden blebs represent a novel hallmark mechanism in pneumococcal pathogenesis, offering new insights and potential therapeutic targets.
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