ArticlebioRxiv : the preprint server for biology2026
Detection of Aggressive Mesenchymal Glioblastoma by Mannose-Weighted CEST MRI.
Behnaz Ghaemi, Hernando Lopez-Bertoni, Shreyas Kuddannaya, Sophie Sall, John Laterra, Guanshu Liu, Jeff W M Bulte
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Behnaz GhaemiRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD.
Hernando Lopez-BertoniDepartment of Oncology; the Johns Hopkins University School of Medicine, Baltimore, MD.
Shreyas KuddannayaRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD.
Sophie SallDepartment of Biomedical Engineering, the Johns Hopkins University School of Medicine, Baltimore, MD.
John LaterraDepartment of Oncology; the Johns Hopkins University School of Medicine, Baltimore, MD.
Guanshu LiuRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD.
Jeff W M BulteRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD.ORCID 0000-0003-1202-1610 Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6MSleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Stewart H Mostofsky · 2020 to 2026
$9.9MChromatin Modifications in GBM-Propagating CellsR01NS096754 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LATERRA, JOHN J · 2017 to 2021
$2.2MIntracellular Self-Assembly of Theranostic Nanoparticles for Enhanced Imaging and Tumor TherapyR01EB030376 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2020 to 2024
$2.1MMolecular determinants of cellular heterogeneity and therapeutic resistance in GBM.R01NS120949 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LOPEZ-BERTONI, HERNANDO MARTIN · 2021 to 2025
$2.0MMultimodal MRI for guiding bacterial cancer therapyR01CA261974 · NCI · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Renyuan Bai, Guanshu Liu · 2022 to 2026
$1.8MBrain Cancer Stem Cell Reprogramming by c-MetR01NS073611 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LATERRA, JOHN J · 2012 to 2016
$1.8MNCI NIH HHS P30 CA006973NCI NIH HHS R01 CA261974NIBIB NIH HHS R01 EB030376NICHD NIH HHS P50 HD103538NINDS NIH HHS R01 NS073611NINDS NIH HHS R01 NS096754NINDS NIH HHS R01 NS120949
6 · The paper itselfAbstract
Glioblastoma (GBM) contain mesenchymal cancer stem cells that drive tumor aggressiveness and recurrence and exhibit aberrant glycosylation during proneural-to-mesenchymal transition. A comprehensive analysis of human GBM transcriptomic datasets revealed an upregulation of 13 genes involved in mannosylation. Histopathological staining of a tissue array representing 35 GBM cases revealed elevated mannose, correlating with increased expression of the mesenchymal marker CD44. Mannose-weighted chemical exchange saturation transfer magnetic resonance imaging (MANw CEST MRI) detected elevated mannose levels in aggressive mesenchymal GBM neurospheres
Identifiers
PMID41726964
PMCPMC12918782
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