Evidence map›Paper›PMID 41726951›Full record

ArticlebioRxiv : the preprint server for biology2026

Rapid Histone Post-Translational Modification Analysis Using Alternative Proteases and Tandem Mass Tags.

Natalie P Turner, Sabyasachi Baboo, Patrick Garrett, Jolene K Diedrich, Michal Bajo, Marisa Roberto, John R Yates

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Natalie P TurnerThe Scripps Research Institute, Department of Integrative and Structural Computational Biology, 10550 North Torrey Pines Rd, La Jolla, CA 92037, United States of America.ORCID 0000-0002-2641-2295
Sabyasachi BabooThe Scripps Research Institute, Department of Integrative and Structural Computational Biology, 10550 North Torrey Pines Rd, La Jolla, CA 92037, United States of America.ORCID 0000-0002-4547-5160
Patrick GarrettThe Scripps Research Institute, Department of Integrative and Structural Computational Biology, 10550 North Torrey Pines Rd, La Jolla, CA 92037, United States of America.ORCID 0000-0002-8434-9693
Jolene K DiedrichThe Scripps Research Institute, Department of Integrative and Structural Computational Biology, 10550 North Torrey Pines Rd, La Jolla, CA 92037, United States of America.ORCID 0000-0001-6489-4558
Michal BajoThe Scripps Research Institute, Department of Translational Medicine, 10550 North Torrey Pines Rd, La Jolla, CA 92037, United States of America.ORCID 0000-0003-1102-2689
Marisa RobertoThe Scripps Research Institute, Department of Translational Medicine, 10550 North Torrey Pines Rd, La Jolla, CA 92037, United States of America.ORCID 0000-0003-0729-3961
John R YatesThe Scripps Research Institute, Department of Integrative and Structural Computational Biology, 10550 North Torrey Pines Rd, La Jolla, CA 92037, United States of America.ORCID 0000-0001-5267-1672

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI AMANDA J ROBERTS · 2003 to 2026
$46.3M
Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Synaptic Mechanisms underlying sex-differences in alcohol use disorderR01AA029841 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2022 to 2026
$2.0M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8M
NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R01 AA029841NIAAA NIH HHS R37 AA017447NIAAA NIH HHS T32 AA007456NIAAA NIH HHS U01 AA013498
6 · The paper itself

Abstract

Histone post-translational modifications (PTMs) alter chromatin dynamics and contribute to the regulation of gene expression in health and disease, yet mass spectrometry-based histone PTM analysis remains constrained by inefficient sample preparation workflows. Here, we develop RIPUP (

Identifiers

PMID41726951
PMCPMC12918826

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.