Evidence map›Paper›PMID 41726936›Full record

ArticlebioRxiv : the preprint server for biology2026

Programmable and Switchable RNA Scaffolds for Synthetic Condensate Engineering in Mammalian Cells.

Zhaolin Xue, Oyeshik Mukherjee, Lan Mi, Yizhan Guo, Ru Zheng, Chang Yuan, Mingxu You

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhaolin XueDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Oyeshik MukherjeeDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Lan MiDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Yizhan GuoMolecular and Cellular Biology Program, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Ru ZhengDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Chang YuanDepartment of Biological Sciences, Mount Holyoke College, South Hadley, Massachusetts 01075, USA.
Mingxu YouDepartment of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.ORCID 0000-0003-3293-9760

Funding

Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
NIGMS NIH HHS T32 GM139789
6 · The paper itself

Abstract

The ability to engineer synthetic biomolecular condensates in living cells offers new opportunities to control intracellular organization, yet robust and programmable RNA-based systems have remained limited. Here, we introduce genetically encoded, modular platforms that generate RNA-driven condensates using nanostar-derived scaffolds. Systematic comparison of repeat-based and

Indexed as

allosteric RNA switchgenetically encoded scaffoldsphase separationprogrammable cellular compartmentalizationRNA condensates

Identifiers

PMID41726936
PMCPMC12918942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.