In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Esteban LunaDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5478-2333 Katheryn A Q CousinsDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-1879-2766 Sheina EmraniDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Sharon X XieDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104 USA.
Winifred TrotmanDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Daniel WeintraubDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104 USA.ORCID 0000-0003-0633-7168 Alice S Chen-PlotkinDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-3387-2038 Edward B LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104 USA.ORCID 0000-0002-4589-1180 David J IrwinDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-5599-5098 Funding
Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Corey T McMillan · 2021 to 2026
$24.8MUnderstanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI David John Irwin, Corey T McMillan · 2020 to 2026
$18.8MProject IV: In Vivo Dissection of Genetic Modifiers on Different Stages of SynucleinopathyP01AG084497 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN · 2024 to 2026
$15.2MUnderstanding biomarkers of cognitive decline in Lewy body diseasesR37NS115139 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN · 2024 to 2026
$2.2MResearch Training Program in Disease-Oriented Neuroscience (R25)UE5NS065745 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Geoffrey Karl Aguirre, HAN-CHIAO ISAAC CHEN · 2024 to 2026
$1.7MNIA NIH HHS P01 AG066597NIA NIH HHS P01 AG084497NIA NIH HHS P30 AG072979NINDS NIH HHS R37 NS115139NINDS NIH HHS UE5 NS065745
6 · The paper itselfAbstract
Lewy body diseases are thought to evolve by the spread of intraneuronal α-synuclein pathology. However, staging models of α-synuclein pathology in the human brain seldom evaluate regions with direct synaptic connectivity to model microglial processes in disease. Here, we address this gap by testing the hypothesis that, within the well-defined synaptic connectivity of the intrahippocampal circuit, neuronal α-synuclein pathology is associated with microglial reactivity. We selected a cohort of autopsy-confirmed Lewy body disease patients with hippocampal neuronal α-synuclein pathology and minimal age-related co-pathologies (
Indexed as
hippocampusLewy body dementiaLewy body diseaseLewy pathologymicrogliaα-synuclein
Identifiers
PMID41726931
PMCPMC12918970
What OpenQuestion holds
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