Evidence map›Paper›PMID 41726928›Full record

ArticlebioRxiv : the preprint server for biology2026

Distinct tau filament folds in familial frontotemporal dementia due to the

Henry S Pan, Gregory E Merz, Alissa Nana Li, Minh Quan Le, Hyunil Jo, Athena Quddus, Anthony Yung, Rian C Kormos, Arthur A Melo, Eliana Marisa Ramos and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Henry S PanDepartment of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1323-037X
Gregory E MerzInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0842-4935
Alissa Nana LiWeill Institute for Neurosciences, Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3474-8044
Minh Quan LeInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0009-0002-4382-6526
Hyunil JoDepartment of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-4863-0779
Athena QuddusInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Anthony YungInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Rian C KormosDepartment of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5831-1464
Arthur A MeloInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9345-1462
Eliana Marisa RamosDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0009-0003-7982-4415
Argentina Lario LagoWeill Institute for Neurosciences, Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Salvatore SpinaWeill Institute for Neurosciences, Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3570-9143
Lea T GrinbergWeill Institute for Neurosciences, Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6809-0618
Howard J RosenWeill Institute for Neurosciences, Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9281-7402
Eric TseInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2082-9006
Maria Luisa Gorno-TempiniWeill Institute for Neurosciences, Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-7426-7782
William F DeGradoDepartment of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-4745-263X
William W SeeleyWeill Institute for Neurosciences, Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1410-2027
Daniel R SouthworthInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7108-9389

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Adam Mark Staffaroni · 2019 to 2026
$120.9M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
VIRAL DEGENERATIVE DEMENTING DISEASE IN AGING (SUPP)P01AG002132 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 1985 to 2024
$51.7M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
NIA NIH HHS P01 AG002132NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS U01 AG045390NIA NIH HHS U01 AG057195NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NINDS NIH HHS U54 NS092089
6 · The paper itself

Abstract

Frontotemporal lobar degeneration with tau inclusions (FTLD-tau) comprise a class of fatal heterogeneous neurodegenerative diseases. Approximately 10% arise from pathogenic MAPT mutations and often cause severe, early-onset disease with pathology that is distinct yet partially overlapping with sporadic cases. Here, we evaluated post-mortem tissue from a patient with FTLD-tau due to

Identifiers

PMID41726928
PMCPMC12918850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.