Evidence map›Paper›PMID 41726906›Full record

ArticlebioRxiv : the preprint server for biology2026

Functional Equivalence of Heat-Inactivated (HI) and Live Probiotic RSB11 in Suppressing Inflammation: Expanding Formulation and Application Potential.

Teodora Nicola, Tanmaya Madhvacharyula, Ajay Ashok, Aryan Mandot, Iman Abdelgawad, Ryann Singh, Kara Siedman, Youfeng Yang, Namasivayam Ambalavanan, Charitharth Vivek Lal

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Teodora NicolaDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Tanmaya MadhvacharyulaDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Ajay AshokDepartment of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Aryan MandotDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Iman AbdelgawadDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Ryann SinghDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Kara SiedmanDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Youfeng YangDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Namasivayam AmbalavananDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
Charitharth Vivek LalDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPDR44HL164156 · NHLBI · RESBIOTIC, INC. · PI NICOLA, TEODORA · 2023 to 2025
$2.3M
Let-7b in BPDR01HL156275 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Namasivayam Ambalavanan · 2023 to 2026
$2.2M
Mechanisms of Pulmonary Microbiota-Induced Inflammation and Vascular Dysfunction in Neonatal Lung InjuryK08HL141652 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAL, CHARITHARTH VIVEK · 2019 to 2023
$838k
NHLBI NIH HHS K08 HL141652NHLBI NIH HHS R01 HL156275NHLBI NIH HHS R44 HL164156
6 · The paper itself

Abstract

The clinical potential of probiotics has been widely recognized, but their translation into reliable therapeutic products has been hindered by major limitations such as undesirable immunogenic responses, the need to maintain viability, instability during storage and transport, and concerns regarding safety in vulnerable populations. Postbiotics, defined as inanimate microbial cells or their components with pro-health activities, overcome many of these limitations by offering enhanced stability, reproducibility, and safety. However, it is very vital to understand if the heat inactivation (conversion of a probiotic to its postbiotic inert form) compromise its functional efficacy. Here, we systematically compared a novel probiotic-derived candidate,

Identifiers

PMID41726906
PMCPMC12918895

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.