Evidence map›Paper›PMID 41726885›Full record

ArticlebioRxiv : the preprint server for biology2026

Convergent strategies for nanobody-mediated inhibition of an epoxide hydrolase.

Adam R Simard, Noor M Taher, Kathryn S Beauchemin, Akaash K Mishra, Andrew P Hederman, Thomas H Hampton, Natalia Vasylieva, Christophe Morisseau, Margaret E Ackerman, Dean R Madden

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam R SimardDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States.ORCID 0000-0001-8175-1196
Noor M TaherDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States.ORCID 0000-0001-8783-120X
Kathryn S BeaucheminDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States.ORCID 0000-0003-2748-4423
Akaash K MishraDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States.ORCID 0000-0002-5964-7525
Andrew P HedermanThayer School of Engineering, Dartmouth, Hanover, New Hampshire, United States.ORCID 0009-0006-2683-1963
Thomas H HamptonDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0003-0543-402X
Natalia VasylievaDepartment of Entomology and Nematology and UCD Comprehensive Cancer Center, University of California, Davis, California, United States.ORCID 0000-0002-4183-7312
Christophe MorisseauDepartment of Entomology and Nematology and UCD Comprehensive Cancer Center, University of California, Davis, California, United States.ORCID 0000-0002-5672-6631
Margaret E AckermanThayer School of Engineering, Dartmouth, Hanover, New Hampshire, United States.ORCID 0000-0002-4253-3476
Dean R MaddenDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States.ORCID 0000-0002-1810-6984

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI MICHAEL L WHITFIELD · 2019 to 2026
$27.2M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Translational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 2018 to 2026
$13.9M
HOST-MICROBE INTERACTIONST32AI007519 · NIAID · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 1997 to 2026
$5.9M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Mechanism of Cif Virulence: A Bacterial Strategy to Subvert Host-Cell DefensesR01AI091699 · NIAID · DARTMOUTH COLLEGE · PI MADDEN, DEAN R, O'TOOLE, GEORGE A. · 2012 to 2016
$2.3M
NCI NIH HHS P30 CA023108NIAID NIH HHS R01 AI091699NIAID NIH HHS T32 AI007519NIDDK NIH HHS P30 DK117469NIEHS NIH HHS R35 ES030443NIGMS NIH HHS P20 GM113132NIGMS NIH HHS P20 GM130454NIGMS NIH HHS P30 GM133893
6 · The paper itself

Abstract

Secreted by

Identifiers

PMID41726885
PMCPMC12918957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.