Evidence map›Paper›PMID 41726875›Full record

ArticlebioRxiv : the preprint server for biology2026

Characterizing the SASP-Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types.

Taylor Russo, Markus Riessland

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Taylor RussoDepartment of Neurobiology and Behavior; Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0003-4564-5366
Markus RiesslandDepartment of Neurobiology and Behavior; Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0003-2592-5045

Funding

Molecular Assessment of Cause and Consequence of Cellular Senescence in Diverse Midbrain Cell Types in Parkinson's DiseaseR01NS124735 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Markus Riessland · 2022 to 2026
$2.0M
NINDS NIH HHS R01 NS124735
6 · The paper itself

Abstract

One of the defining phenotypes of a senescent cell is the senescence-associated secretory phenotype (SASP), which can propagate senescence in neighboring cells both

Indexed as

brain cell typesligand-receptor pairsparacrine spreadingSenescencesenescence-associated secretory phenotype (SASP)

Identifiers

PMID41726875
PMCPMC12918862

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.