Evidence map›Paper›PMID 41726868›Full record

ArticlebioRxiv : the preprint server for biology2026

datadrivenhypothesis.org: A resource for metabolic gene discovery through integrated pathway co-essentiality mapping.

Matthew D Hirschey, Pol Castellano-Escuder, John Bradley

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew D HirscheyDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-4541-5376
Pol Castellano-EscuderDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
John BradleyDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
Studies on the Mechanisms by which SIRT5 Regulates Aging and DiseaseR01AG045351 · NIA · DUKE UNIVERSITY · PI HIRSCHEY, MATTHEW D · 2014 to 2023
$4.4M
Post-Translational and Epigenetic Control of Branched-Chain Amino Acid MetabolismR01DK115568 · NIDDK · DUKE UNIVERSITY · PI HIRSCHEY, MATTHEW D · 2018 to 2021
$1.9M
NCI NIH HHS P30 CA014236NIA NIH HHS R01 AG045351NIDDK NIH HHS R01 DK115568
6 · The paper itself

Abstract

datadrivenhypothesis.org (DDH) integrates gene dependency, expression, literature data, and beyond from ~20,000 human genes to reveal hidden metabolic connections. Through pathway-level co-essentiality analysis with novelty scoring, DDH uncovered unexpected links including Complex II coupled to purine nucleotide biosynthesis. This broad platform offers intuitive tools for hypothesis generation via gene queries, pathway analysis, and network visualization, plus publication-ready downloads. Automated updates make DDH a dynamic resource, bridging genes with unknown function to actionable metabolic insights.

Identifiers

PMID41726868
PMCPMC12918783

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.