ArticleTetrahedron2025
Cobalt-Catalyzed Alkene Hydrohalogenation via Hydrogen Atom Transfer.
Article in Tetrahedron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cobalt-Catalyzed Radical Ligand Transfer (RLT) Enables Remote-Markovnikov Hydroamination of Alkenes.Angewandte Chemie (International ed. in English) · 2026Article
- Catalytic Markovnikov hydrophosphorylation of unactivated olefins via a radical-polar crossover rearrangement.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Alkene hydrohalogenation is a fundamental transformation for the synthesis of organohalides, key intermediates in organic synthesis, pharmaceuticals, and materials science. Traditional ionic methods with hydrogen halides are limited by harsh conditions, poor functional group tolerance, and regioselectivity issues. Recently, cobalt-catalyzed hydrohalogenation via metal-hydride hydrogen atom transfer (MHAT) has emerged as a versatile and radical-based alternative, enabling mild conditions, broad functional group tolerance, and tunable regioselectivity. This mini-review provides a comprehensive overview of the development in cobalt-catalyzed alkene hydrohalogenation via MHAT, with particular emphasis on methodological innovations, substrate scopes, mechanistic principles, and emerging applications. The continued growth of this field is poised to expand the synthetic utility and sustainability of alkene hydrofunctionalization, opening new avenues for programmable C-X bond formation across diverse chemical contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.