ArticleInternational journal of cardiology. Heart & vasculature2026
The role of quantitative cardiovascular MRI and late gadolinium enhancement patterns in differentiating late-onset Anderson-Fabry disease (c.640-801G > A) from hypertrophic cardiomyopathy: a case-control study.
Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: To evaluate the utility of cardiovascular magnetic resonance imaging (CMR) in distinguishing Anderson-Fabry disease (AFD) harboring the c.640-801G > A mutation from hypertrophic cardiomyopathy (HCM). Methods and results: We enrolled 30 AFD patients, 30 age- and sex-matched HCM patients, and 30 healthy controls (HC). All participants underwent CMR (3.0 T). Left ventricular hypertrophy (LVH) prevalence was high in both AFD and HCM groups (P = 0.12). AFD patients exhibited significantly greater left ventricular lateral wall thickness compared to both HCM and HC (P < 0.001), and a significantly lower interventricular septal to lateral wall thickness ratio (IVS/LW) than HCM (P < 0.001). Late gadolinium enhancement (LGE) was significantly more frequent in the basal inferolateral and apical segments in AFD compared to HCM (P < 0.001 and P = 0.039, respectively). Native T1 values were significantly lower in AFD than HCM in the global LV, septal LV, and within LGE regions (all P < 0.001). Compared to HC, AFD patients had significantly lower septal native T1 (P < 0.001), but comparable global LV native T1 (P = 0.155). Native T1 cut-offs effectively discriminated AFD from HCM: septal native T1 ≤ 1247 ms, global native T1 ≤ 1256 ms, and LGE region native T1 ≤ 1334 ms. Septal native T1 demonstrated the strongest discriminatory capacity. Conclusion: CMR effectively differentiates AFD patients with the c.640-801G > A mutation from HCM. Key discriminators include lower native T1 values (Caution against pseudo-normalization), higher prevalence of basal inferolateral LGE, and more symmetric LVH in AFD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.