ArticleACS omega2026
Eutectic Mixture Approach for Enhancing Solubility, Permeability, and Bioactivity of Curcumin: Influence of Ferulic Acid and Nicotinamide as Coformers.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Synergistic Neuroprotective Effect of Honokiol and Magnolol Against Amyloid-β and MPPInternational journal of molecular sciences · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
Curcumin, the active constituents of turmeric, possess a wide range of therapeutic properties but are limited by poor aqueous solubility and low bioavailability. This study aimed to enhance the solubility and biological activities of curcumin by forming eutectic mixtures with ferulic acid and nicotinamide as coformers. The eutectic mixtures were prepared in a 1:1 molar ratio using liquid-assisted grinding and solvent evaporation methods and characterized using FTIR, DSC, and PXRD. Their physicochemical properties (solubility, stability, and permeability) and biological activities (antioxidant, anti-inflammatory, neuroprotective, antiosteoporotic, and anticancer effects) were subsequently evaluated. The mixtures, curcumin-ferulic acid (Cur-Fer) and curcumin-nicotinamide (Cur-NCM), exhibited eutectic characteristics and demonstrated significantly improved solubility and permeability. Among the tested compounds, Cur-Fer exhibited the highest enhancement, with 2.0- and 1.6-fold increases in solubility and permeability, respectively, compared to curcumin. Both Cur-Fer and Cur-NCM exhibited enhanced anticancer activity (selectivity indexes of 2.43 and 2.34, respectively, at 100 μM), improved neuroprotective effects against MPP
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Registered trials
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