ArticleACS omega2026
T Cell Receptor Co-Stimulation Through Magnetogenetic Tools: A Platform for Wireless Rewiring of Cellular Signaling.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lysosomal magneto-mechanics rewire immunity.Cell research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic biology offers innovative strategies to control cell function for therapeutic applications. Here, we present a magnetogenetic platform for T cell receptor (TCR) costimulation using magnetic fields to achieve noninvasive activation of T cells. We employed engineered TRPV1, TRPV4, and electromagnetic perceptive gene (EPG) constructs in HEK293, Jurkat, and primary human T cells. Calcium imaging confirmed functional activation of these tools, while qPCR and proteomic analyses revealed downstream effects on activation markers, calcium signaling, mitochondrial function, and membrane integrity. In Jurkat and primary T cells, magnetic stimulation alone reduced activation signatures, but when combined with antigenic stimulation, it significantly enhanced T cell activation. This dual-modality response indicates that magnetogenetic tools can serve as tunable costimulators of TCR signaling. Our findings highlight the potential of wireless, magnetically controlled systems to precisely modulate immune cell behavior, with implications for the development of next-generation cell-based immunotherapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.