ArticleACS omega2026
Effervescent-Assisted Dissolving Microneedle Array Patches for Localized Tetracycline Delivery: A Three-Layer Design for Rapid-Onset Antimicrobial Therapy in Superficial Skin Infections.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
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Abstract
Dissolving microneedle array patches (DMNAPs) offer promise for minimally invasive antimicrobial therapy but face challenges in achieving rapid drug release and complete needle deposition. This study developed and characterized a novel three-layer DMNAP incorporating an effervescent separation mechanism for enhanced tetracycline hydrochloride (TCH) delivery to infected superficial tissues. DMNAPs were fabricated using sequential casting with drug-loaded poly-(vinyl alcohol) (PVA) microneedles, an effervescent separation layer (sodium bicarbonate/tartaric acid), and a polyvinylpyrrolidone (PVP) backing. Mechanical properties, skin penetration efficiency, drug release kinetics, antimicrobial efficacy against
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Registered trials
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