Evidence map›Paper›PMID 41726641›Full record

ArticleACS omega2026

Effervescent-Assisted Dissolving Microneedle Array Patches for Localized Tetracycline Delivery: A Three-Layer Design for Rapid-Onset Antimicrobial Therapy in Superficial Skin Infections.

Sonthaya Chaiarwut, Chasuda Choipang, Pairayaphak Ngamplang, Pitt Supaphol

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sonthaya ChaiarwutThe Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand.
Chasuda ChoipangThe Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand.
Pairayaphak NgamplangThe Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand.
Pitt SupapholThe Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand.ORCID https://orcid.org/0000-0003-3804-0756

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dissolving microneedle array patches (DMNAPs) offer promise for minimally invasive antimicrobial therapy but face challenges in achieving rapid drug release and complete needle deposition. This study developed and characterized a novel three-layer DMNAP incorporating an effervescent separation mechanism for enhanced tetracycline hydrochloride (TCH) delivery to infected superficial tissues. DMNAPs were fabricated using sequential casting with drug-loaded poly-(vinyl alcohol) (PVA) microneedles, an effervescent separation layer (sodium bicarbonate/tartaric acid), and a polyvinylpyrrolidone (PVP) backing. Mechanical properties, skin penetration efficiency, drug release kinetics, antimicrobial efficacy against

Identifiers

PMID41726641
PMCPMC12917785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.