Evidence map›Paper›PMID 41726639›Full record

ArticleACS omega2026

Copper-Mediated Late-Stage Radical Trifluoromethylation of Pyrazole-Type Scaffolds.

Lucie S Eisen, Jan H Griwatz, Sven Ruf, María Méndez, Enrique Gomez-Bengoa

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucie S EisenDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, Manuel Lardizabal 3, 20080 San Sebastián, Spain.
Jan H GriwatzSanofi R&D, Integrated Drug Discovery, Industriepark Höchst, Building G838, 65926 Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0003-2028-0938
Sven RufSanofi R&D, Integrated Drug Discovery, Industriepark Höchst, Building G838, 65926 Frankfurt am Main, Germany.
María MéndezSanofi R&D, Integrated Drug Discovery, Industriepark Höchst, Building G838, 65926 Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0002-6832-2714
Enrique Gomez-BengoaDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country, Manuel Lardizabal 3, 20080 San Sebastián, Spain.ORCID https://orcid.org/0000-0002-8753-3760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trifluoromethylated pyrazoles and their derivatives are of great interest due to their biological and pharmacological relevance. However, efficient methods for their preparation via late-stage trifluoromethylation strategies remain limited. Herein, we report a practical and efficient method for the direct trifluoromethylation of pyrazoles using in situ generated CF

Identifiers

PMID41726639
PMCPMC12917629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.