Evidence map›Paper›PMID 41726614›Full record

ArticleACS omega2026

Activity-Cloud Organization of Shine-Dalgarno Sequences to Guide Translation Engineering in

Pavel Zach, Yadira Boada, Jesús Pico, Alejandro Vignoni

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pavel ZachSynthetic Biology and Biosystems Control Lab, Instituto de Automática e Informática Industrial, Universitat Politècnica de València, València 46022, Spain.ORCID https://orcid.org/0009-0000-4882-7283
Yadira BoadaSynthetic Biology and Biosystems Control Lab, Instituto de Automática e Informática Industrial, Universitat Politècnica de València, València 46022, Spain.ORCID https://orcid.org/0000-0001-5677-2702
Jesús PicoSynthetic Biology and Biosystems Control Lab, Instituto de Automática e Informática Industrial, Universitat Politècnica de València, València 46022, Spain.ORCID https://orcid.org/0000-0003-4144-3521
Alejandro VignoniSynthetic Biology and Biosystems Control Lab, Instituto de Automática e Informática Industrial, Universitat Politècnica de València, València 46022, Spain.ORCID https://orcid.org/0000-0001-9977-7132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modifying the six-nucleotide Shine-Dalgarno (SD) core motif inside the ribosome binding site (RBS) constitutes a straightforward approach for tuning bacterial translation. However, existing methods for adjusting the effective translation rate (ETR) lack predictability. Even single-nucleotide substitutions can induce substantial alterations in translation efficiency. Moreover, this unpredictability is exacerbated by variations in the leader sequence, spacer region, or coding context. By focusing on the SD core as a key, experimentally tunable determinant of translation initiation in

Identifiers

PMID41726614
PMCPMC12917692

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.