ArticleACS omega2026
Two-Step Algorithmic Selection of Interspecies Sequence-Mismatch-Based Housekeeping Genes for Precise Gene-Expression Assessment in PBMC-Humanized NSG Mice.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
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Abstract
Accurate normalization of gene expression is crucial in humanized mouse models, in which human cells are engrafted into immunodeficient mice. However, selecting the appropriate housekeeping genes remains a challenge. We aimed to identify and validate robust housekeeping genes for gene-expression analysis for human cells residing in different tissues of human peripheral blood mononuclear cell (hPBMC)-humanized NSG mice. We employed a multifaceted approach combining computational analysis and
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