ArticleOpen life sciences2026
Coagulation parameter-based nomogram for the diagnosis of obstetric antiphospholipid syndrome and its subtypes.
Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Currently available classification criteria for obstetric antiphospholipid syndrome (OAPS) are often overly strict and may miss a considerable number of patients with so-called "non-criteria-defined OAPS". We aimed to establish a diagnostic nomogram based on clinical and laboratory parameters to facilitate the diagnostic efficacy for OAPS by incorporating both criteria - and non-criteria - defined OAPS. We retrospectively analyzed the clinical and laboratory data of 45 patients with criteria-defined OAPS, 57 with non-criteria-defined OAPS, and 80 age-matched healthy controls between September 2023 and March 2024. We established a nomogram for OAPS based on the risk factors identified through logistic regression and evaluated its performance using the receiver-operating characteristic curve, calibration curve, and decision curve analysis. Antinuclear antibody titer, as well as levels of complement C3, anti-β2 glycoprotein I, thrombin-antithrombin complex, and Von Willebrand factor were independent risk factors for OAPS (
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