ArticleOpen life sciences2026
Attenuation of microglial aryl hydrocarbon receptor alters astrocyte activation and chronic pain sensitization in aging.
Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The aryl hydrocarbon receptor is expressed in non-sensory cells in the cochlea and regulates hair cell survival.Frontiers in molecular neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to examine differences in aryl hydrocarbon receptor (AHR) expression between microglia in aged and adult mice and to investigate the impact of microglial AHR attenuation on chronic pain sensitization. Immunofluorescence staining was performed to assess AHR expression in microglia. BV2 microglial cells were treated with lipopolysaccharides (LPS), the AHR agonist FICZ, and the AHR antagonist CH223191. The resulting supernatant was used to culture C8-DIA astrocytes, and inflammatory factor levels were quantified using quantitative real-time polymerase chain reaction. AHR expression in spinal dorsal horn microglia was significantly lower in aged mice compared to adult mice. Furthermore, microglial AHR expression was found to regulate astrocyte activation. AHR expression in spinal dorsal horn microglia is markedly reduced in aged mice. Activated microglia with diminished AHR expression induce astrocytes more strongly and enhance astrocyte-mediated inflammation, contributing to prolonged hyperalgesia in aged mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.