Evidence map›Paper›PMID 41726503›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2024

Automated Image Registration Method for In Vivo Confocal Microscopy of the Corneal Sub-basal Nerve Plexus.

Nathan Siu, Micah Vinet, Parth Shettiwar, Thai Tran, Kyle Chen, Theo Stoddard-Bennett, Clémence Bonnet, Corey Arnold, William Speier, Sophie X Deng

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Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nathan SiuJules Stein Eye Institute, UCLA, Los Angeles, CA.
Micah VinetJules Stein Eye Institute, UCLA, Los Angeles, CA.
Parth ShettiwarBiomedical AI Research Lab, UCLA, Los Angeles, CA.
Thai TranMedical Informatics Home Area, Graduate Programs in Bioscience, UCLA, Los Angeles, CA.
Kyle ChenBiomedical AI Research Lab, UCLA, Los Angeles, CA.
Theo Stoddard-BennettJules Stein Eye Institute, UCLA, Los Angeles, CA.
Clémence BonnetJules Stein Eye Institute, UCLA, Los Angeles, CA.
Corey ArnoldMedical Informatics Home Area, Graduate Programs in Bioscience, UCLA, Los Angeles, CA.
William SpeierMedical Informatics Home Area, Graduate Programs in Bioscience, UCLA, Los Angeles, CA.
Sophie X DengJules Stein Eye Institute, UCLA, Los Angeles, CA.

Funding

Ex Vivo Expansion of Human Limbal Stem Cells for TransplantationR01EY021797 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sophie Deng · 2012 to 2026
$5.1M
Development of small-molecule Wnt mimetics for corneal epithelial cell regenerationR01EY028557 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DENG, SOPHIE, ZHENG, JIE J. · 2018 to 2021
$2.0M
NEI NIH HHS R01 EY021797NEI NIH HHS R01 EY028557
6 · The paper itself

Abstract

In vivo confocal microscopy (IVCM) assesses corneal innervation in the sub-basal nerve plexus but is typically quantified manually from a single z-scan, limiting biomarker extrapolation for diagnosing limbal stem cell deficiency (LSCD). We developed an automated 3D reconstruction method of IVCM image volumes to improve sub-basal nerve density quantification. Our dataset comprised 99 IVCM stacks from 63 LSCD eyes (51 patients) and 23 stacks from 15 normal eyes. We designed an image registration algorithm combining phase correlation and homography transformation, which achieved a pairwise image correlation of 0.69 and mutual information of 0.60, significantly outperforming manual registration (0.60 and 0.43, respectively; p<0.001). Validation on an independent dataset of 325 volume scans from 24 eyes of 12 unilateral, severe LSCD patients yielded a correlation of 0.75 and MI of 0.76. This method enhances sequential IVCM scan alignment and supports more accurate, reproducible 3D evaluation of LSC biomarkers.

Indexed as

CorneaImaging, Three-DimensionalAlgorithmsHumansLimbal Stem Cell DeficiencyMicroscopy, Confocal

Identifiers

PMID41726503
PMCPMC12919528

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.