ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2024
Developing RxNorm Extension: A Step Toward Global Drug Data Harmonization in Observational Drug Research.
Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- VO: The Vaccine Ontology.Scientific data · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper presents RxNorm Extension (RxE), a standardized drug vocabulary system designed to harmonize drug data across international databases. RxE integrates drugs from multiple national drug repositories, enhancing global drug safety and effectiveness research by standardizing drug representations in disparate drug vocabularies to a structure following RxNorm, a reference standard in the US. We developed an attribute-based mapping approach that improves consistency and reduce manual data processing. Based on 12 vocabularies included, we observe similar dose form and ingredient usage patterns but many more brand names available worldwide. The quality of RxE depends on the thorough examination of the source vocabulary, where challenges include discrepancies in brand names, poorly structured dosage forms, and faulty dosages. Despite the challenges, RxE has been used in numerous clinical and methodological studies. Future directions focus on expanding coverage, improving mapping automation, and fostering international collaboration to optimize global drug safety and effectiveness efforts.
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Identifiers
41726498PMC12919553What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.