Evidence map›Paper›PMID 41726485›Full record

Trial reportAMIA ... Annual Symposium proceedings. AMIA Symposium2024

Earlier ICU Transfer after CONCERN Early Warning System Score Escalation Reduced Sepsis-related Mortality: Results from a Multi-site Pragmatic Cluster Randomized Controlled Trial.

Rachel Y Lee, Kenrick D Cato, Patricia C Dykes, Graham Lowenthal, Sandy Cho, Haomiao Jia, Temiloluwa Daramola, Sachleen Tuteja, Sarah C Rossetti

Abstract readMulticenter StudyPragmatic Clinical Trial
In one paragraph

Trial report in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel Y LeeColumbia University, Department of Biomedical Informatics, New York, NY.
Kenrick D CatoUniversity of Pennsylvania, Philadelphia, PA.
Patricia C DykesBrigham and Women's Hospital, Boston, MA.
Graham LowenthalBrigham and Women's Hospital, Boston, MA.
Sandy ChoNewton -Wellesley Hospital, Newton, MA.
Haomiao JiaColumbia University, School of Nursing, New York, NY.
Temiloluwa DaramolaColumbia University, Department of Biomedical Informatics, New York, NY.
Sachleen TutejaColumbia University, Department of Biomedical Informatics, New York, NY.
Sarah C RossettiColumbia University, Department of Biomedical Informatics, New York, NY.

Funding

Reducing Health Disparities Through Informatics - Genomics SupplementT32NR007969 · NINR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SUZANNE BAKKEN, Rebecca Schnall · 2002 to 2026
$7.9M
Communicating Narrative Concerns Entered by RNs (CONCERN)R01NR016941 · NINR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Kenrick Dwain Cato, Sarah Collins Rossetti · 2017 to 2026
$6.7M
NINR NIH HHS R01 NR016941NINR NIH HHS T32 NR007969
6 · The paper itself

Abstract

Early recognition and timely escalation of care are critical for improving sepsis outcomes. This post-hoc analysis of a multi-site clinical trial examined whether the timing of ICU transfer following CONCERN Early Warning System (EWS) score escalation was associated with in-hospital mortality among patients later diagnosed with sepsis. Among 54 patients with CONCERN score changes prior to unanticipated ICU transfer, shorter score-change-to-ICU-transfer time intervals were significantly associated with lower odds of in-hospital death. A 36-hour threshold emerged as a potential inflection point; all patients transferred after this time interval died in the hospital. No significant differences were observed in the ICU-arrival-to-sepsis time interval between early and late transfers. These findings highlight the importance of acting promptly on early warning systems and suggest that CONCERN EWS may offer a meaningful lead time for intervention improving outcomes for sepsis patients.

Indexed as

Early Warning ScoreHospital MortalityIntensive Care UnitsPatient TransferSepsisAgedFemaleHumansMaleMiddle AgedTime Factors

Identifiers

PMID41726485
PMCPMC12919569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.