Evidence map›Paper›PMID 41726369›Full record

ArticleFrontiers in oncology2025

Synchronous malignant rhabdoid tumor of the kidney and adrenal neuroblastoma in an infant treated with proton beam therapy: a case report and literature review.

Wei Han, Huaida Teng, Junlei Shi, Nan Zhang, Jargal Tumendemberel, Ping Lu, Jie Wang, Jie Zheng, Xinan Liu, Deguang Meng and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Repurposing metformin for choriocarcinoma: targeting the AMPK/mTOR pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei HanDepartment of Pediatric Oncology, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Huaida TengDepartment of Pediatric Surgery, Beijing Children's Hospital Baoding Hospital, Capital Medical University, Baoding, China.
Junlei ShiDepartment of Pediatric Surgery, Beijing Children's Hospital Baoding Hospital, Capital Medical University, Baoding, China.
Nan ZhangDepartment of Pathology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Jargal TumendemberelPediatric Proton Beam Therapy Center, Hebei Yizhou Cancer Hospital, Zhuozhou, China.
Ping LuDepartment of Pathology, Hebei Yizhou Cancer Hospital, Zhuozhou, China.
Jie WangDepartment of Radiotherapy Physics and Technology, Hebei Yizhou Cancer Hospital, Zhuozhou, China.
Jie ZhengPediatric Proton Beam Therapy Center, Hebei Yizhou Cancer Hospital, Zhuozhou, China.
Xinan LiuNuclear Medicine Department/Pediatric Proton Beam Therapy Center, Hebei Yizhou Cancer Hospital, Zhuozhou, China.
Deguang MengDepartment of Pediatric Surgery, Beijing Children's Hospital Baoding Hospital, Capital Medical University, Baoding, China.
Shosei ShimizuPediatric Proton Beam Therapy Center, Hebei Yizhou Cancer Hospital, Zhuozhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report and literature review presents a 4-month-old infant with a synchronous malignant rhabdoid tumor of the kidney and adrenal neuroblastoma, an exceptionally rare combination without established treatment guidelines. Following surgical resection, proton beam therapy (14 Gy in 10 fractions) was administered to the abdominal-pelvic tumor bed with stringent organ-sparing objectives. Contemporary literature supports proton beam therapy's (PBT's) dosimetric advantages for organ preservation in pediatric abdominal malignancies. At 1-year follow-up, the patient remained disease-free, with preserved renal function and normal skeletal development, supporting PBT's role in minimizing late effects while achieving local control in infant malignancies when conventional photon radiotherapy would pose substantial developmental risks.

Indexed as

case reportIMRT (intensity-modulated radiation therapy)infantneuroblastoma malignant rhabdoid tumorpencil beam scanning proton beam therapyproton beam therapyradiotherapy

Identifiers

PMID41726369
PMCPMC12918047

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.