ReviewRSC advances2026
Ferroptosis and immunity: rewiring the tumor microenvironment for therapy.
Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Exploring Ferroptosis: A Key Mechanism in Respiratory System Diseases and its Therapeutic Potential.Applied biochemistry and biotechnology · 2026Review
- Review
- What Is-and What Is Not-Immunogenic Cell Death? Functional Definitions, Experimental Standards, and Common Pitfalls.International journal of molecular sciences · 2026Review
- Insights into FACT in Cancers with Targeted Therapeutic Implications.Molecular and cellular biology · 2026Review
- Revisiting macrophage metabolic reprogramming in metabolic dysfunction-associated steatotic liver disease: mechanisms, regulation, and therapeutic breakthroughs.Frontiers in immunology · 2026Review
- Circular RNAs as molecular bridges: dual regulation of ferroptosis and immunity in cancer.Frontiers in immunology · 2026Review
- NCOA4 as a regulatory switch linking DNA damage to lipid peroxidation in radiation response.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferroptosis, a distinct form of programmed cell death driven by iron-dependent lipid peroxidation, has emerged as a critical player in cancer biology, influencing both tumor progression and therapeutic responses. This review explores the multifaceted role of ferroptosis within the tumor microenvironment (TME), focusing on its dual potential to promote anti-tumor immunity and immune evasion. Key molecular mechanisms regulating ferroptosis, including the roles of GPX4, SLC7A11, and ACSL4, are examined alongside their interplay with immune cells such as CD8+ T cells, dendritic cells, and macrophages. The review addresses the immunosuppressive effects of ferroptosis-induced signals such as prostaglandin E2 and damage-associated molecular patterns that foster tumor growth. Furthermore, therapeutic strategies leveraging ferroptosis to overcome resistance in cancer treatment, including its integration with immunotherapy and radiotherapy, are discussed. This study underscores the potential of targeting ferroptosis to enhance cancer therapy while emphasizing the need for further research to optimize its application in immunotherapy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.