Evidence map›Paper›PMID 41725986›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Quantitative evaluation of fracture healing progression in rat femurs with modal damping factor and conventional methods.

Stavros Chalikias, George Anastassopoulos, John Sarris, Stefania Athanasopoulou, Malvina Orkoula, Christos Kontoyannis, Vassilis Kostopoulos, Spyridon Psarras, Nikolaos Papaioannou, Efstathios Chronopoulos and 2 more

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Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Stavros Chalikias *Orthopaedic Department, NHS Ayrshire and Arran, Trauma and Orthopaedics, University Hospital Crosshouse, Kilmarnock, United Kingdom.
George Anastassopoulos *Merchant Marine Academy, Aspropyrgos, Greece.
John Sarris *Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece.
Stefania Athanasopoulou *Laboratory of Pharmaceutical Analysis, Department of Pharmacy, University of Patras, Patras, Greece.
Malvina Orkoula *Laboratory of Pharmaceutical Analysis, Department of Pharmacy, University of Patras, Patras, Greece.
Christos Kontoyannis *Laboratory of Pharmaceutical Analysis, Department of Pharmacy, University of Patras, Patras, Greece.
Vassilis Kostopoulos *Applied Mechanics and Vibrations Lab, Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece.
Spyridon Psarras *Applied Mechanics and Vibrations Lab, Department of Mechanical Engineering and Aeronautics, University of Patras, Patras, Greece.
Nikolaos Papaioannou *Laboratory for Research of Musculoskeletal System "Th. Garofalidis", General Hospital of Attica "KAT", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Efstathios Chronopoulos *Laboratory for Research of Musculoskeletal System "Th. Garofalidis", General Hospital of Attica "KAT", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Ismene Dontas *Laboratory for Research of Musculoskeletal System "Th. Garofalidis", General Hospital of Attica "KAT", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Sofia Panteliou *Laboratory of Machine Elements, University of Patras, Mechanical Engineering and Aeronautics, Patras, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantitative determination of bone fracture healing through objective measurements on the fracture area during healing phases is of paramount importance. In this study, simultaneous modal damping factor (MDF) testing was compared to peripheral quantitative computed tomography (pQCT), Raman spectroscopy (RS), and absorbed and fracture energy. MDF is a non-invasive index based on the model's dynamic characteristics that applies vibration excitation. The method has been successfully applied as a structural integrity monitoring tool for defective conventional and advanced materials, including bones. We investigated whether MDF could identify when a functional and biomechanically adequately strengthened callus developed in osteotomized rat femurs. The measured property value intervals indicate that MDF correlates with all properties and detects the bone quality changes due to fracture and fracture healing with higher sensitivity than other methods. MDF monitors bone fracture healing and correlates with all parameters examined in a more accurate and sensitive way than conventional methods. Research findings support MDF as the most convenient of the methods examined for monitoring the bone fracture healing process.

Indexed as

animal modelbonedampingfracturehealingmodal

Identifiers

PMID41725986
PMCPMC12920479

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