Evidence map›Paper›PMID 41725892›Full record

ArticleIEEE transactions on radiation and plasma medical sciences2026

Semi-Monolithic Detectors for TOF-DOI Brain PET: Optimization of Time, Energy, and Positioning Resolutions With Varying Surface Treatments.

Fiammetta Pagano, Francis Loignon-Houle, David Sanchez, Nicolas A Karakatsanis, Jorge Alamo, Sadek A Nehmeh, Antonio J Gonzalez

Abstract read
In one paragraph

Article in IEEE transactions on radiation and plasma medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fiammetta PaganoInstituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC-Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-9938-6799
Francis Loignon-HouleInstituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC-Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-8931-2016
David SanchezInstituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC-Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0003-1062-5664
Nicolas A KarakatsanisDepartment of Radiology, Weill Cornell Medical College, New York, NY 10065 USA.ORCID 0000-0001-7326-3053
Jorge AlamoOncovision, 46022 Valencia, Spain.
Sadek A NehmehDepartment of Radiology, Weill Cornell Medical College, New York, NY 10065 USA.
Antonio J GonzalezInstituto de Instrumentación para Imagen Molecular (I3M), Centro mixto CSIC-Universitat Politècnica de València, 46022 Valencia, Spain.ORCID 0000-0001-6742-5626

Funding

Ultra-High Performance Brain-dedicated PET scanner for Neurology and Neuro-oncology imagingR01CA275942 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Sadek Nehmeh · 2023 to 2026
$2.3M
NCI NIH HHS R01 CA275942
6 · The paper itself

Abstract

Semi-monolithic detectors, a hybrid configuration combining the benefits of pixelated arrays and monolithic blocks, present a compelling and cost-effective solution for positron emission tomography (PET) scanners with both time-of-flight (TOF) and depth-of-interaction (DOI) capabilities. In this work, we evaluate four LYSO-based semi-monolithic arrays with various surface treatments, read out with the PETsys TOFPET2 ASIC, to identify the optimal configuration for a novel brain PET scanner. The chosen array, featuring ESR on all surfaces except for the black-painted lateral pixelated ones, achieved 15.9 ± 0.6 % energy resolution and 253 ± 15 ps detector time resolution (DTR). neural network with multilayer perceptron architectures were used to estimate the annihilation photon impact position, yielding average accuracies of 3.7 ± 1.1 mm and 2.6 ± 0.7 mm (FWHM) along the DOI and monolithic directions, respectively. The comparative analysis of the four arrays also prompted an investigation into light sharing in semi-monolithic detectors, supported by a GATE-based simulation framework which was designed to complement the experimental results and confirm the observed trends in time resolution. By refining the detector design based on semi-monolithic geometry and optimized surface crystal treatment to enhance positioning accuracy, this study contributes to the development of a next-generation brain PET scanner, with competitive performance but at a moderate cost.

Indexed as

Depth-of-interaction (DOI)Monte Carlo simulationsneural networks (NNs)semi-monolithic detectorstime-of-flight (TOF)-positron emission tomography (PET)

Identifiers

PMID41725892
PMCPMC12922655

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.