ArticleJournal of bone and joint infection2026
Safety of locally applied antibiotics in orthopaedic trauma surgery: descriptive results from a prospective cohort study.
Article in Journal of bone and joint infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antibiotic therapy holds an integral role in the prevention and treatment of fracture-related infection (FRI). Because local concentrations after systemic administration are limited by the potential for side effects, the local application of antibiotics serves as a valuable adjunct. One concern with the local administration of high amounts of aminoglycosides and vancomycin is the absorption into the systemic circulation, leading to detrimental effects on renal function. In this study, serum antibiotic concentration and renal function were measured in patients treated for open fractures or FRI using local antibiotics at 6, 24 and 48 h postoperatively. Afterwards, laboratory analyses were continued daily until the concentration dropped beneath the lower limit of quantification (LLOQ) (0.22 mg L
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