ArticleMatter2025
Modular salt-induced nanostructures formed by a functionalized dipeptide system.
Article in Matter, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Article
- Atomic-precision π-driven peptide hydrogel nanofibers with ordered water channels.Nature communications · 2026Article
- The resolution revolution revisited.IUCrJ · 2026Article
- Lithium-selective supramolecular assembly and capture by tripeptide gelators.Chemical science · 2026Article
- Tutorial: Machine-Learning-Based CREASE-2D Analysis of 2D SAXS Profiles to Characterize Anisotropic Nanostructures in Soft Materials.ACS measurement science au · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Self-assembling peptides have great potential in nanotechnology. We introduce the naphthalene-modified dipeptide isoleucine-phenylalanine (2NapIF) as a modular system for creating various nanostructures via self-assembly, including fibers, nanotubes, and bundles, resulting from the addition of salts. Mechanical stirring is crucial for developing certain supramolecular architectures. Using cryo-electron microscopy (cryo-EM), we found that the structural organization of these nanostructures is primarily driven by hydrophobic stacking of aromatic rings and hydrogen bonding among peptide atoms. The diversity in packing arises from the ability of 2NapIF to adopt multiple conformations, with our studies revealing 18 distinct conformations within a KCl-induced nanotube. This results in a large asymmetric unit containing 18 molecules, with 18 conformations, that could never have been predicted with current tools. This modular system has potential applications in creating innovative materials, including robust, salt-responsive "noodles" that exceed a meter in length.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.