ArticleFrontiers in microbiology2026
Gut microbiota affects the progression of colorectal cancer under the intervention of exercise.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) ranks as the third most common cancer globally, accounting for 10% of cases, and is the second leading cause of cancer-related death. Exercise can maintain/restore the body's internal balance at multiple levels to prevent pathologies, although its mechanism is complex and involves multiple systems. While physical activity improves colon cancer patients' quality of life and reduces discomfort, how it works remains unclear. To explore this, we constructed a rat CRC model. We performed 16S rRNA and nontargeted metabolomics sequencing and analyzed the results to screen distinct intestinal microbes and their metabolites. To clarify the links among these microbes/metabolites, intestinal barrier function, and inflammatory markers, we used qRT-PCR, immunohistochemistry, and ELISA to verify the effects of exercise intervention on intestinal barrier function and inflammatory factor expression. We also checked the expression of the PCNA gene (a proliferation index) to assess cell proliferation.
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