ArticleFrontiers in microbiology2026
Human papillomavirus 16 E6 oncoprotein promotes up-regulation of RNA-binding protein Sam68 in head and neck cancer.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Head and neck squamous cell carcinoma (HNSCC) are a heterogeneous group of tumors linked to diverse risk factors, such as tobacco and alcohol use, as well as human papillomavirus (HPV) infection. HPV16 E6 and E7 oncoproteins are the main players of cell transformation, with the E6*I isoform increasing during neoplastic progression. The aim of this study was to evaluate the role of cellular splicing factors in the production of E6*I in HPV16-related HNSCC. We have evaluated the levels of splicing factors mRNA (HNRNPA1, HNRNPA2B1, SRSF1, SRSF2, SRSF3, BRM and SAM68) as well as HPV16 E6 and E6*I mRNAs by qPCR in HNSCC as well as in SCC152 and SCC154 cell lines. Overall, 42.4% of HNSCC tested positive for HPV16 DNA, and among these 54% expressed E6*I mRNA. The SRSF3, BRM and SAM68 transcripts were significantly higher in HPV-positive compared to HPV-negative HNSCC (
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