ArticleFrontiers in neurology
Thyroid hormone deficiency induces endolymphatic hydrops: neurological and histopathological evidence from an experimental rat model.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
Background: Vestibular disorders, particularly Ménière's disease, represent significant neurological conditions affecting balance, spatial orientation, and quality of life. While endolymphatic hydrops is recognized as the pathological hallmark of Ménière's disease, the relationship between thyroid dysfunction and vestibular pathology remains incompletely understood. Clinical observations suggest associations between hypothyroidism and vestibular symptoms, yet experimental evidence demonstrating causality is lacking. Objective: To investigate whether surgically-induced hypothyroidism causes endolymphatic hydrops development in an experimental rat model and to characterize the histopathological changes in vestibular structures. Methods: Twelve male Wistar albino rats were randomly allocated to total thyroidectomy ( Results: Thyroidectomized rats developed significant biochemical hypothyroidism with elevated TSH (mean difference: 0.378 μIU/mL, 95% CI: 0.183-0.573, Conclusion: This study provides the first direct experimental evidence that thyroid hormone deficiency induces endolymphatic hydrops in all examined vestibular structures. These findings establish a mechanistic link between hypothyroidism and vestibular pathology, with important implications for the neurological evaluation and management of patients presenting with vestibular symptoms and comorbid thyroid dysfunction.
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