ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Cells rely on surface receptors to sense and initiate signalling cascades essential for numerous cellular processes, but engineering of synthetic genetic circuits to sense and rewire receptor activities for user-defined cellular functions remains a challenge. Here we report a synthetic receptor-signalling induced transcription (RESIT) circuit that enables sensing and reprogramming membrane-localized receptor activation to pre-defined transcriptional programs. The RESIT system is designed based on receptor activation mediated split protease complementation and release of membrane-tethered synthetic transcriptional modules. We show that RESIT design is generally applicable to different transcriptional factors and various split viral proteases. This system is further engineered to probe Ca
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