Evidence map›Paper›PMID 41725592›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Elucidating the Stereodirecting Effect of C-4 Acyl Groups on Galactosyl Donors.

Floor Ter Braak, Frank F J de Kleijne, Teun van Wieringen, Peter H Moons, Jonathan Martens, Jos Oomens, Peter A Korevaar, Paul B White, Thomas J Boltje

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Solid-Phase Glycolipid Synthesis Expedites Liposome Functionalization.Journal of the American Chemical Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Floor Ter BraakInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Frank F J de KleijneInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Teun van WieringenInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Peter H MoonsInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Jonathan MartensInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Jos OomensInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Peter A KorevaarInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Paul B WhiteInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.
Thomas J BoltjeInstitute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0001-9141-8784

Funding

NWO-VIDI grant
6 · The paper itself

Abstract

The stereoselective synthesis of 1,2-cis glycosidic bonds is a significant challenge in carbohydrate chemistry. 1,2-Cis galactosides can be obtained by using C-4 acyl protection groups as a stereodirecting group, yet the underlying mechanism that steers selective galactosylation has remained elusive. Herein, we investigate the stereodirecting effect of C-4 acyl groups in galactosides using glycosylation reactions, exchange NMR spectroscopy and DFT-calculations. We found no experimental evidence for C-4 dioxepanium ion formation through C-4 acyl neighboring group participation. Instead, β-glycosyl triflates were detected using exchange NMR which could afford α-galactosides via S

Indexed as

density functional theorygalactosylationneighboring group participationnuclear magnetic resonancereaction mechanisms

Identifiers

PMID41725592
PMCPMC13023705

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.