Development of covalent inhibitors for bacterial histidine kinases.

Patricia D Rodriguez, Conrad A Fihn, Manibarsha Goswami, Erin E Carlson

Abstract read

In one paragraph

Article in Chemical communications (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patricia D RodriguezDepartment of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, 55455, USA. carlsone@umn.edu.

Conrad A FihnDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, USA.ORCID http://orcid.org/0000-0002-9253-1479

Manibarsha GoswamiDepartment of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, 55455, USA. carlsone@umn.edu.

Erin E CarlsonDepartment of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, 55455, USA. carlsone@umn.edu.ORCID http://orcid.org/0000-0001-8287-8893

Funding

Chemical Strategies to Map Bacterial Response to Environmental ChangeR35GM153306 · NIGMS · UNIVERSITY OF MINNESOTA · PI Erin Elizabeth Carlson · 2024 to 2026

$1.6M

Discovery of New Antibacterial Targets: Probes and Inhibitors of Histidine Kinase ProteinsR01GM134538 · NIGMS · UNIVERSITY OF MINNESOTA · PI CARLSON, ERIN ELIZABETH · 2020 to 2023

$1.2M

NIGMS NIH HHS R01 GM134538NIGMS NIH HHS R35 GM153306

6 · The paper itself

Abstract

Antivirulence therapies offer an alternative strategy against antimicrobial resistance. We synthesized 2-aminobenzothiazole sulfonyl fluoride analogs for covalent histidine kinase inhibition.

Indexed as

BenzothiazolesHistidine KinaseProtein Kinase InhibitorsMolecular StructureStructure-Activity RelationshipSulfinic AcidsBenzothiazolesHistidine KinaseProtein Kinase InhibitorsSulfinic Acidssulfuryl fluoride

Identifiers

PMID41725556

DOI10.1039/d5cc06657c

PMCPMC13010972

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.