An atypical case of granulomatosis with polyangiitis in a 15-year-old girl presenting with pyoderma gangrenosum-like ulcers on the face.

Brandon Levian, Vignesh Ravi, Kevin K Wu, Shanice McKenzie, Brittney DeClerck, Gene Kim, Christine Cole, Binh Ngo

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Article in Dermatology online journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Brandon LevianKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Vignesh RaviDepartment of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Kevin K WuDepartment of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Shanice McKenzieDepartment of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Brittney DeClerckDepartment of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Gene KimDepartment of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Christine ColeForefront Dermatology, Thousand Oaks, CA, USA.

Binh NgoDepartment of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Granulomatosis with polyangiitis (GPA) is an uncommon form of antineutrophil cytoplasmic antibodies-associated necrotizing vasculitis characterized by symptoms affecting the ears, nose, and throat, along with respiratory issues and kidney involvement. Although GPA is extremely rare among children, delayed diagnosis can have fatal consequences. We report a unique instance of GPA in a 15-year-old girl exhibiting solitary pyoderma gangrenosum-like ulcers on the face. After an extensive evaluation, the patient was diagnosed with GPA and demonstrated an excellent response to dual therapy combining rituximab and corticosteroids. Although exceptionally uncommon, clinicians must consider GPA as a possible condition in the differential diagnosis of individuals presenting with pyoderma gangrenosum-like ulcers.

Indexed as

Facial DermatosesGranulomatosis with PolyangiitisPyoderma GangrenosumSkin UlcerAdolescentDiagnosis, DifferentialFemaleHumansImmunosuppressive AgentsRituximabImmunosuppressive AgentsRituximabANCAantineutrophil cytoplasmic antibodiesGPAgranulomatosis with polyangiitisimmunosuppresionpyoderma gangrenosumrituximab

Identifiers

PMID41725471

DOI10.1016/j.gene.2023.148024

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