Evidence map›Paper›PMID 41725378›Full record

ArticleCell transplantation

Effects of human embryonic stem cell-derived Schwann cells for nerve regeneration after facial nerve injury.

Myung Chul Yoo, Jong Ha Lee, Jae Min Lee, Yong Jun Kim, Seung Geun Yeo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Myung Chul YooDepartment of Physical Medicine & Rehabilitation, Kyung Hee University Medical Center, Seoul, Republic of Korea.ORCID 0000-0003-2088-9612
Jong Ha LeeDepartment of Physical Medicine & Rehabilitation, Kyung Hee University Medical Center, Seoul, Republic of Korea.
Jae Min LeeDepartment of Otorhinolaryngology, Head and Neck Surgery, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Yong Jun KimDepartment of Pathology, College of Medicine, Kyung Hee University, Seoul, South Korea.ORCID 0000-0002-5374-712X
Seung Geun YeoDepartment of Otorhinolaryngology, Head and Neck Surgery, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Facial nerve transection frequently results in incomplete functional recovery despite microsurgical repair due to axonal misalignment and limited intrinsic regenerative capacity. Schwann cells (SCs) are essential for peripheral nerve repair, supporting axon elongation, remyelination, and neurotrophic signaling. Human embryonic stem cell-derived Schwann cells (hESC-SCs), including Schwann cell precursors (SCPs) and immature SCs, constitute a scalable source of cells for tissue-engineered nerve grafts. This study investigated whether silicone conduits loaded with hESC-SCs could enhance facial nerve regeneration following complete transection in rats. hESCs were differentiated into SCPs or immature SCs using a stepwise

Indexed as

Facial Nerve InjuriesHuman Embryonic Stem CellsNerve RegenerationSchwann CellsAnimalsCell DifferentiationFacial NerveFemaleHumansRatsRats, Sprague-Dawleyfacial nerve injuryhuman embryonic stem cellsnerve regenerationSchwann cellssilicone conduit

Identifiers

PMID41725378
PMCPMC12929842

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.