ArticlePediatric pulmonology2026
Respiratory Oscillometry and Multimodal Lung Function Assessment of Elexacaftor/Tezacaftor/Ivacaftor Response in Children and Young Adults With Cystic Fibrosis.
Article in Pediatric pulmonology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo date, there is no data on forced oscillation technique (FOT) as a tool to evaluate elexacaftor/tezacaftor/ivacaftor (ETI) modulator in young patients with cystic fibrosis (pwCF).
objectiveOur study aimed to assess the effect of a 6-month ETI treatment on FOT parameters and compare it to the effect on spirometry and nitrogen multiple-breath washout (N
methodForty-nine pwCF (median age 12.39 years, 59.2% male) were assessed with spirometry, N
resultsA significant change was observed 6 months after receiving ETI in height, weight, BMI, Rs5z-score, Xs5z-score, AXz-score, FEV
conclusionsOur preliminary data suggest that oscillometry parameters showed a significant improvement after ETI treatment among all genotype groups. More data are required to assess whether and which FOT parameters could be used as surrogates of LCI or spirometry for the long-term follow-up of pwCF.
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