ArticleJournal of nanobiotechnology2026
Electro-controlled assembled of biphasic guided bone regeneration membrane for healing of diabetic periodontal bone defects.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Design and applications of barrier membranes for guided bone regeneration.Bioactive materials · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundRegeneration of periodontal bone defects has long posed a significant challenge to clinicians. Traditional guided bone regeneration (GBR) membranes have a single function, making it difficult to achieve immunoregulation and bone regeneration under the inflammatory and infection-prone conditions of diabetes. To address this, we developed a "one-step synergistic electro-assembly" technique and electrically controlled assembly techniques to engineer a Janus collagen membrane with a spatially programmable, biphasic structure.
resultsThis novel manufacturing process utilizes electrical signals to simultaneously control collagen self-assembly into a gradient Janus structure and chemically reduce graphene oxide (GO) via Ferulic Acid (FA) in situ. This creates a seamlessly integrated "conductive-antioxidant" interface without the need for toxic reducing agents or physical lamination. It enhances the applicability of collagen membranes in scenarios, where they carry and sustainably release bioactive drugs and promote the regeneration of both soft and hard tissues. Here, this dual-function membrane integrates osteoinductive and barrier properties within a single construct, enabling ordered, site-specific release of ferulic acid (FA) and graphene oxide (GO). The FA side (barrier membrane layer) confers antioxidant and anti-inflammatory effects, while the FA/GO-enhanced osteogenic side (inductive membrane layer) increases electrical conductivity, promoting electrostimulated bone formation. Meanwhile, the controlled release of FA and GO exerts synergistic antibacterial, anti-inflammatory, and osteogenic effects, ultimately enhancing periodontal bone regeneration in diabetic rat models. The inductive membrane layer enhanced M2 macrophage polarization to modulate the immune microenvironment, and activated Ca
conclusionsThese findings demonstrate that the electrically assembled Janus membrane offers a promising platform for multifunctional tissue repair, advancing the clinical repair of complex bone defects under inflammatory conditions.
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