Evidence map›Paper›PMID 41724892›Full record

ArticleEnvironmental monitoring and assessment2026

Is the presence of estradiol benzoate in cow feces environmentally safe?

Lucas L C Guidoni, Érico Kunde Corrêa, José V V Isola, Bernardo G Gasperin, Arnaldo D Vieira, Rafael G Mondadori, Eduardo Schmitt, Michel D Gerber, Flávio M R Silva, Thomaz Lucia

Abstract read
In one paragraph

Article in Environmental monitoring and assessment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lucas L C GuidoniCentro de Engenharias, NEPERS, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Érico Kunde CorrêaCentro de Engenharias, NEPERS, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
José V V IsolaFaculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Bernardo G GasperinFaculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Arnaldo D VieiraFaculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Rafael G MondadoriInstituto de Biologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Eduardo SchmittFaculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Michel D GerberInstituto Federal de Educação, Pelotas, RS, Brazil.
Flávio M R SilvaFederal University of Alagoas, Maceió, AL, Brazil.
Thomaz LuciaFaculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil. tluciajr@gmail.com.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303293/2022-5Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 21/2551-0002254-0-07/201
6 · The paper itself

Abstract

Estradiol benzoate can be used, among other veterinary protocols, to induce lactation in non-pregnant cows with reproductive failures. However, the use of estrogens in livestock is controversial due to concerns about environmental contamination from hormone residues. The objective of this study was to evaluate the ecotoxicity of estradiol benzoate excreted in cow feces using plant and animal bioassays. Onion and celosia seeds, earthworms (Eisenia fetida), and microcrustaceans (Daphnia magna) were exposed to fecal samples from cows with induced lactation and to aqueous solutions containing estradiol benzoate at 10-100 µg/kg. Exposure to fecal samples did not impair seed germination, earthworm reproduction, or the behavior of either animal bioindicator (P > 0.05) and was associated with increased adult earthworm weight (P < 0.05), according to statistical comparisons of means and measures of dispersion. No effects were observed at any tested concentrations of estradiol benzoate on any response (P > 0.05). These findings indicate that feces from cows treated with estradiol benzoate for lactation induction exerted limited ecotoxicological effects on growth, behavior, and reproduction of plant and animal bioindicators.

Indexed as

EstradiolFecesSoil PollutantsAnimalsCattleEnvironmental MonitoringFemaleOligochaetaEstradiolestradiol 3-benzoateSoil PollutantsBioindicatorsEcotoxicityEstradiolFecesGermination

Identifiers

PMID41724892
PMCPMC12926234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.