ReviewArchives of microbiology2026
Biological characteristics, human cell interaction mechanisms, and differential clinical outcomes of infection by Brucella melitensis, Brucella abortus, Brucella suis, and Brucella canis.
Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central challenge in brucellosis prevention and control stems from the marked heterogeneity among Brucella species. This review establishes a "Virulence-Metabolism-Temporal and Spatial" (VMT) model and proposes a Virulence Index (VI) formula to systematically compare the biological characteristics and host interaction mechanisms of four pathogenic Brucella species: B. melitensis, B. abortus, B. suis, and B. canis. Our analysis reveals that these species represent an evolutionary continuum from high virulence with acute dissemination to low virulence with tissue localization. B. melitensis achieves deep immune stealth and triggers systemic spread through its ultra-efficient Type IV Secretion System (T4SS), specific lipid A modifications, and potent apoptosis inhibition. B. suis specifically targets bone marrow and induces bone destruction via acid-inducible T4SS activation and iron metabolic hijacking. B. abortus elicits partial autophagic clearance due to insufficient T4SS efficiency, resulting in self-limiting infections. B. canis provokes intense inflammatory responses through its rough lipopolysaccharide (LPS) and exhibits defective T4SS function, precluding persistent infection establishment. The VMT model elucidates the causal chain linking molecular characteristics to cellular interactions and clinical phenotypes, demonstrating that virulence depends on the precise balance between immune evasion efficiency and host cell fate regulation. These findings provide a theoretical foundation for species-specific diagnosis, stratified therapeutics, and One Health-based precision prevention and control of brucellosis.
Indexed as
Identifiers
41724843What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.